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Uncovering the underlying genetics leads to an understanding about disease pathophysiology

Genetic risk factors may provide clues into modifiable environmental risk factor

Genetic variant and molecules identified through genetic studies can serve as biomarkers to identify at risk population for disease prevention

Knowledge about genetic risk factor may allow for personalized medicine in the future.

This review has highlighted many methodological shortcomings in the studies reviewed; further high-quality trials need to be published. Evidence-based guidelines rather than therapist preference should serve as a framework from which therapists should derive the most effective treatment.